A few natural products vie for the Canine Cushing’s market. You mentioned Supraglan and Cushex, neither of which am I qualified to talk about although I’m sure they are fine products. My recommendation is one of our Primalix naturopathic-veterinary Herbal Extract “Functional Food Drops” formulated specifically to ameliorate and eliminate symptoms of Cushing’s in all dog breeds. It’s called Primalix CortiQuel and everything I have to say about this safe and effective herbal remedy can be found at Cushing’s in Dogs.
Diagnosing Cushing’s syndrome can be difficult. Routine laboratory tests including a complete blood cell count, biochemistry panel and urinalysis are important to rule out other disease such as diabetes, which may cause similar clinical signs. A series of specialized confirmatory tests are then warranted to measure the response of the adrenal gland to the administration of hormones (ACTH stimulation test, low or high dose dexamethasone suppression test). These are blood tests but they take several hours (sometimes all day) and are necessary to make a diagnosis. In some dogs, results of these confirmatory tests are ambiguous and require abdominal ultrasound, or further imaging (MRI or CT scan) to identify whether a tumor can be seen directly in the adrenal glands or in the pituitary gland (brain).
The drug's most common side effects are poor or reduced appetite, vomiting, lack of energy, diarrhea, and weakness. Occasionally, more serious side effects, including bloody diarrhea, collapse, severe sodium/potassium imbalance, and destruction of the adrenal gland may occur, and may result in death. In 2014, with input from CVM, the manufacturer updated the information about patient monitoring and side effects on the package insert. Although not proven to be caused by Vetoryl, some additional side effects reported to CVM and now included on the package insert are adrenal insufficiency, shaking, elevated liver enzymes and elevated kidney tests.