Cortisone can dramatically reduce inflammation and speed up wound healing. With cystic acne lesions, healing usually begins immediately. Despite doctors regularly using cortisone in a local manner to help one acne lesion at a time, no studies have ever been performed on these local cortisone injections with regards to acne lesion healing. However, two studies in 1954 evaluated the effect of intravenous cortisone on acne as a whole. One study showed that intravenous cortisone reduced acne in all six patients who were enrolled. 2 The other study reported that systemic cortisone reduced acne in only 5 of 17 patients studied, although they did not report how cortisone was administered. 3 Both of these studies used a very small sample size and are outdated, so the results should be interpreted with caution. Despite this lack of published evidence that supports the use of local cortisone shots to treat acne, in the real world, dermatologists routinely use cortisone shots with consistently good results.