The US Food and Drug Administration (FDA) has issued public health advisories related to fentanyl patch dangers. Among these, in July 2005, the FDA issued a Public Health Advisory,  which advised that "deaths and overdoses have occurred in patients using both the brand name product Duragesic and the generic product." In December 2007, as part of this continuing investigation, the FDA issued a second Public Health Advisory  stating, "The FDA has continued to receive reports of deaths and life-threatening side effects in patients who use the fentanyl patch. The reports indicate that doctors have inappropriately prescribed the fentanyl patch... In addition, the reports indicate that patients are continuing to incorrectly use the fentanyl patch..."
SUMMARY AND SUGGESTIONS There is no doubt that inhibiting eicosanoid synthesis by modern drugs therapies is effective for many people in reducing the inflammation and the accompanying pain of many diseases, particularly arthritis. It has been shown that regular consumption of aspirin, even in small doses of about 80 mg/day, reduces risk of heart attack and colon cancer, and this effect appears to be mediated, at least in part, by inhibiting eicosanoids. For those suffering from serious diseases, many wish to avoid using the standard drugs, or avoid using them frequently, due to experience of side effects or concerns about side effects. Prolonged use of corticosteroid drugs and NSAIDS has been linked to serious reactions in some individuals. In order to take reasonable steps to minimize the symptoms of these diseases through means other than relying on the drugs, it is important to understand the process by which the inflammation and other disease manifestations (., platelet sticking, bronchiospasms) occur.
You do not need large amounts of grapefruit juice or grapefruit to slow down your body’s ability to metabolize prohormones, and other medication and supplements. Even a glass of regular grapefruit juice could prevent your body from absorbing medications or supplements by almost 47 percent. Grapefruit juice’s effects on the CYP34A enzyme slowly wears off. Even 24 hours post ingestion, the juice could still prevent prohormone metabolism in excess of 15 percent. Therefore, get in touch with your doctor before administering prohormone supplements or merging grapefruit or its juice with any other supplement or medication.