AB - PURPOSE OF REVIEW: Adrenal masses are highly prevalent, found in 5% of the population. Differentiation of benign adrenocortical adenoma from adrenocortical carcinoma is currently hampered by the poor specificity and limited evidence base of imaging tests. This review summarizes the results of studies published to date on urine steroid metabolite profiling for distinguishing benign from malignant adrenal masses. RECENT FINDINGS: Three studies have described cohorts of at least 100 patients with adrenal tumors showing significant differences between urinary steroid metabolite excretions according to the nature of the underlying lesion, suggesting significant value of steroid metabolite profiling as a highly accurate diagnostic test. SUMMARY: Steroid profiling is emerging as a powerful novel diagnostic tool with a significant potential for improving the management for patients with adrenal tumors. Although the current studies use gas chromatography–mass spectrometry for proof of concept, widespread use of the method in routine clinical care will depend on transferring the approach to high-throughput tandem mass spectrometry platforms. The use of computational data analysis in conjunction with urine steroid metabolite profiling, that is, steroid metabolomics, adds accuracy and precision.
If you are a tested athlete, if you’re going to supplement with anabolic steroids you must understand steroid detection times thoroughly if you stand a chance. For the tested athlete, you will be somewhat limited in-regards to which steroids you can use. For example, if you’re a truly tested athlete, Nandrolone based steroids can never be used as their detection time stretches past a year. Many testosterone compounds must also be avoided; especially large esters or testosterone mixtures, but the smaller or ester free versions are often an option. Of course, many athletes who are tested are only done so for show, and if that’s the case, well, it really doesn’t matter what you use. In any case, for show or a legitimate test, if you understand steroid detection times there’s really no reason for you to have a problem.