The renal effects of nonsteroidal anti-inflammatory drugs summary and recommendations

Acute treatment with the bisphosphonates was well tolerated by the animals at doses up to 10 mg/kg ibandronate, up to 3 mg/kg zoledronate, and 200 mg clodronate twice daily. However, rats given either 20 mg/kg ibandronate or 6 mg/kg zoledronate did not gain weight during the 4-day observation period. All rats given the highest dose of zoledronate (10 mg/kg) showed marked signs of poor condition, reduced food consumption and weight loss. Two of the three rats treated with 10 mg/kg zoledronate for electron microscopic examination only, died on day 3 after dosing and the third animal had to be euthanised.

The renal effects of nonsteroidal anti-inflammatory drugs summary and recommendations

the renal effects of nonsteroidal anti-inflammatory drugs summary and recommendations

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the renal effects of nonsteroidal anti-inflammatory drugs summary and recommendationsthe renal effects of nonsteroidal anti-inflammatory drugs summary and recommendationsthe renal effects of nonsteroidal anti-inflammatory drugs summary and recommendationsthe renal effects of nonsteroidal anti-inflammatory drugs summary and recommendationsthe renal effects of nonsteroidal anti-inflammatory drugs summary and recommendations

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